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Though aon the UKPDS showed that just being in the intervention group reduced heart attacks and strokes 10 years after the follow up period, imagine how many heart attacks and strokes might have been prevented had patients maintained glycemic control over a much longer period of time!

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This can never be a cause of hypoglycemia in patients with mature type 1 diabetes, since there is no endogenous insulin production to stimulate.

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Once the cells have enough glucose for their immediate needs, the excess is stored as fat.

Pharmacodynamically, detemir has decreased insulin and IGF-1 receptor affinity.

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Also, a chemical in a rat poison no longer in use has been shown to cause diabetes if ingested.

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In patients with type 1 diabetes, detemir and NPH were equally effective in maintaining glycemic control, although detemir was administered at a higher molar dose.

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There are not yet enough data to definitively say whether body fat or blood lipid changes cause glucose abnormalities, blood sugar disorders contribute to lipodystrophy, some common mechanism underlies both manifestations, or the conditions occur together but are otherwise independent.

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Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3).

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Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes.

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